Ulrich Kronthaler
This page will be under construction for ever, to reach constant improvement.
Some details about me:
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born: 1967 in Bonn (F.R.Germany)
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Studying in Tübingen until 1992
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1992/3 Diploma on: Dopamine glutamate interactions following striatal 6-OHDA lesions
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Since Feb. 1995 PhD Thesis: Behavioural and neurochemical characterization of the metabotropic glutamate receptors in the basal ganglia of the rat
There is a picture of me
available too, taken at the place where i usually work and where all these pages where designed.
Recent publications:
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Ulrich O. Kronthaler, Werner J. Schmidt (1996)
1S,3R-ACPD has cataleptogenic effects and reverses MK 801-and, less pronounced, D,L amphetamine-induced locomotion. Eur. J. Pharmacol, (subm).
Abstract:
The purpose of this study was to examine the motor effects of
(1S,3R) 1 amino cyclopentane 1,3 dicarboxylic acid (1S,3R ACPD), an agonist at metabotropic
glutamate receptors, its interaction with dizocilpine (MK 801), a N methyl D aspartate- (NMDA) receptor
antagonist, and with D,L amphetamine, an indirect dopamine receptor agonist. 1S,3R ACPD (20, 30, 40, 80 microg)
evoked prominent locomotor and exploratory deficits in an open field hole board test and a moderate akinesia and
rigidity in a catalepsy test (30, 40, 80 microg). MK 801 (0.08, 0.16, 0.32 mg/kg i.p.) as well as D,L amphetamine (1.0,
2.0, 3.0 mg/kg i.p.) potently reversed 1S,3R ACPD-induced (80 microg) catalepsy.
MK 801 and D,L amphetamine, administred alone, induced motor stimulation. 1S,3R ACPD (80 microg) reversed the
effects of the two lower doses of MK 801. 1S,3R-ACPD reversed D,L amphetamine-induced motor stimulation to a
minor extend than that of MK-801.
Thus motor deficits induced by 1S,3R-ACPD were reversed by both, NMDA receptor blockade and dopamine
receptor activation. 1S,3R ACPD reversed motor stimulation, induced by NMDA receptor blockade and, however
less pronounced, that by dopamine receptor activation.
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I will attend the "2nd International meeting on metabotropic Glutamate receptors" in Taormina (Italy) in Sept. 1996, for which my abstract
is available.
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I addition i intend to visit the "7th Interrnational Conference on
in vivo
Methods in Santa Cruz de Tenerife (Spain) in Sept. 1996, for which my abstract
is available too.
Document created July 24th, 1996
Ulrich Kronthaler,
ulrich.kronthaler@student.zdv.uni-tuebingen.de(ulrich.kronthaler@student.zdv.uni-tuebingen.de)